Welcome to Shanghai E-Tong Chemical Co.,Ltd.!
About usHistoryOur CultureNews
Research & DevelopmentQuality SystemRegistration Support
Active IngredientFormulationsPacking

Product Category

Contact Us

Add: No.23, Lane 5398, Shenzhuan Road, Songjiang District, Shanghai, China

Tel: +86-21-51698968

Fax: +86-21-64138597

E-mail: admin@etongchem.com

Skype Sayid (General Manager)

Sayid Song

Insecticides

Current Location: Home > Products > Insecticides

Chlorpyrifos

IRAC 1B organophosphate

NOMENCLATURE
Common name chlorpyriphos-éthyl ((m) France); chlorpyriphos ((m) F-ISO, JMAF); chlorpyrifos (BSI, E-ISO, ANSI, ESA, BAN) IUPAC name O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate
Chemical Abstracts name O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothioate CAS RN [2921–88–2] EC no. 220–864–4 Development codes Dowco 179 (Dow) Official codes OMS 971; ENT 27 311 Smiles code CCOP(=S)(OCC)Oc1nc(Cl)c(Cl)cc1Cl
PHYSICAL CHEMISTRY
Composition Tech. is ≥97%. Mol. wt. 350.6 M.f. C9H11Cl3NO3PS Form Colourless crystals, with a mild mercaptan odour. M.p. 42–43.5 °C B.p. >400 °C V.p. 2.7 mPa (25 °C) Kow logP = 4.7 Henry 6.76 × 10-1 Pa m3 mol-1 (calc.) S.g./density 1.44 (20 °C) Solubility In water c. 1.4 mg/l (25 °C). In benzene 7900, acetone 6500, chloroform 6300, carbon disulfide 5900, diethyl ether 5100, xylene 5000, iso-octanol 790, methanol 450 (all in g/kg, 25 °C). Stability Rate of hydrolysis increases with pH, and in the presence of copper and possibly of other metals that can form chelates; DT50 1.5 d (water, pH 8, 25 °C) to 100 d (phosphate buffer, pH 7, 15 °C).
COMMERCIALISATION
History Insecticide reported by E. E. Kenaga et al. (J. Econ. Entomol., 1965, 58, 1043). Commercially introduced by Dow Chemical Co. (now Dow AgroSciences) during 1965. Patents US 3244586 Manufacturers Agriphar; Agro Chemicals India; Agrochem; Aimco; Anhui Huaxing; Bhagiradha; Bharat; CAC; Cheminova; Chizhou Sincerity; Crystal; Devidayal; Dow AgroSciences India; Drexel; Excel Crop Care; Fengle; Fengshan; Ficom; Gharda; Gujarat Pesticides; Hebei Kaidi; Hubei Sanonda; India Pesticides; Jiangsu Baoling; Lianyungang Liben; Lucava; Luxembourg; Makhteshim-Agan; Meghmani; Nagarjuna Agrichem; Rallis; Red Sun; Sabero; Saeryung; Sanonda Zhengzhou; Shandong Huayang; Sharda; Sinon; Siris; Sudarshan; Sundat; Tagros; Xinan; ZheJiang DongFeng; Zhejiang Xinnong; Zhejiang Yongnong; Zhong-Xi
APPLICATIONS
Biochemistry Cholinesterase inhibitor. Mode of action Non-systemic insecticide with contact, stomach, and respiratory action. Uses Control of Coleoptera, Diptera, Homoptera and Lepidoptera in soil or on foliage in over 100 crops, including pome fruit, stone fruit, citrus fruit, nut crops, strawberries, figs, bananas, vines, vegetables, potatoes, beet, tobacco, soya beans, sunflowers, sweet potatoes, peanuts, rice, cotton, alfalfa, cereals, maize, sorghum, asparagus, glasshouse and outdoor ornamentals, turf, and in forestry. Also used for control of household pests (Blattellidae, Muscidae, Isoptera), mosquitoes (larvae and adults) and in animal houses. Phytotoxicity Non-phytotoxic to most plant species when used as recommended. Poinsettias, azaleas, camellias, and roses may be injured. Formulation types CS; DP; EC; GR; UL; WG; WP. Compatibility Incompatible with alkaline materials.
PRODUCTS
Selected products ‘Agromil’ (Westrade) ; ‘Chlorofet’ (Vapco) ; ‘Chlorofos’ (Mobedco) ; ‘Clarnet’ (Lainco) ; ‘Clinch II’ (Barclay) ; ‘Cyren’ (Cheminova) ; ‘Destroyer’ (Agriphar) ; ‘Deviban’ (Devidayal) ; ‘Dhanvan’ (Dhanuka) ; ‘Dorsan’ (Inquiport, Luxembourg) ; ‘Dursban’ (Dow AgroSciences) ; ‘Force’ (Nagarjuna Agrichem) ; ‘Fullback’ (Reposo) ; ‘Heraban’ (Heranba) ; ‘Hilban’ (Hindustan) ; ‘Hollywood’ (Rocca) ; ‘Kirfos’ (Kemio) ; ‘Knocker’ (Ingeniería Industrial) ; ‘Lorsban’ (Dow AgroSciences) ; ‘Mukka’ (Crop Health) ; ‘Panda’ (Cequisa) ; ‘Phantom’ (Sundat) ; ‘Pyriban’ (Aimco) ; ‘Pyrifoz’ (Hubei Sanonda) ; ‘Pyrinex’ (Makhteshim-Agan) ; ‘Radar’ (RPG) ; ‘Robon’ (Ramcides) ; ‘Strike’ (Biostadt) ; ‘Tafaban’ (Rallis) ; ‘Terraguard’ (Gharda) ; ‘Tricel’ (Excel Crop Care) mixtures ‘Duet’ (+ cypermethrin) (Agria, Agria) ; ‘Kuaikele’ (+ beta-cypermethrin) (Zhongwei, Zhongwei) ; ‘Twister’ (+ alpha-cypermethrin) (Aimco, Aimco) ; ‘Nurelle’ (+ cypermethrin) (Dow AgroSciences India, Dow AgroSciences India) Other products ‘Agroban’ (Chemvet) ; ‘Agrosban’ (AgroSan) ; ‘Alise’’ (Sipcam S.p.A.) ; ‘Ballad’ (Headland) ; ‘Bar 500’ (Sanonda Australia) ; ‘Beer-Chlor’ (Trithin) ; ‘Blaze’ (Indofil) ; ‘Callifos’ (Arysta LifeScience EAME) ; ‘Cannon’ (Nagarjuna Agrichem) ; ‘Chevron 48’ (DAPT) ; ‘Chlorban’ (United Phosphorus) ; ‘Chlorguard’ (Gharda) ; ‘Chlorodust’ (Agro Chemicals India) ; ‘Chlorophos’ (Papaeconomou) ; ‘Chloroplus’ (Agro Chemicals India) ; ‘Choke’ (Afrasa) ; ‘Ciclone’ (Sapec) ; ‘Compas’ (Agricultura Nacional) ; ‘Condor’ (CAS) ; ‘Crossfire’ (Bayer CropScience) ; ‘Dorsan’ (Luxembourg) ; ‘Duragro’ (Agropharm) ; ‘Empire’ (Dow AgroSciences) ; ‘Equity’ (Dow AgroSciences) ; ‘Eraser’ (Independent Agribusiness) ; ‘Etilval’ (IQV Italia) ; ‘Fantom’ (P I Industries) ; ‘Geodinfos’ (Siapa) ; ‘Gilfos’ (Gharda) ; ‘Gilphos’ (Gharda) ; ‘Govern’ (Tenkoz) ; ‘Inaclor’ (Sipcam Inagra) ; ‘Kloroban’ (BEC) ; ‘Klorpan’ (Nufarm Industria Quimica) ; ‘Klorpan’ (Nufarm Industria Quimica) ; ‘Krishan’ (Krishi Rasayan) ; ‘Lirifos’ (Plaaskem S.A.) ; ‘Lock-On’ (Dow AgroSciences) ; ‘Loxiran’ (Neudorff) ; ‘Lucaban’ (Lucava) ; ‘Luqpirifos’ (LUQSA) ; ‘Megaban’ (Doğal) ; ‘Micropir’ (Agrimport) ; ‘Molban’ (Gujarat Pesticides) ; ‘Navigator’ (Gharda) ; ‘Nufos’ (Cheminova) ; ‘Pepejal’ (Gharda) ; ‘Pestan’ (Efthymiadis) ; ‘Pestban’ (Agrochem) ; ‘Pestox’ (Ancom) ; ‘Pilot’ (Gharda) ; ‘Pirate’ (Nufarm Ltd) ; ‘Piricaps’ (Chemia) ; ‘Pirichem’ (Chemia) ; ‘Piridane’ (Chimiberg) ; ‘Pirifos’ (Herbos, IQV) ; ‘Presor’ (Premier.Shukuroglou) ; ‘Priban’ (Hektaş) ; ‘Pychlorex’ (Protex) ; ‘Pyrinox’ (Crystal) ; ‘Pyristar’ (Makhteshim-Agan) ; ‘Raider’ (Jubilant Organosys) ; ‘Rebound’ (Zagro) ; ‘Regatta’ (Gharda) ; ‘Rimi’ (Sintagro) ; ‘Robust’ (Sabero) ; ‘Rotiofen Gold’ (Siapa) ; ‘Saurus’ (Helena) ; ‘Shooter’ (Chemiplant) ; ‘Spannit’ (Barclay) ; ‘Sulban’ (Sulphur Mills) ; ‘SuSCon’ (Nufarm) ; ‘suSCon Green’ (Nufarm) ; ‘Suxon vert’ (Nufarm SAS) ; ‘Termex’ (Planters Products) ; ‘Termicide’ (Vapco) ; ‘Thitan’ (Agrimport) ; ‘Trishul’ (Coromandel) ; ‘Voodoo 300’ (Australia) (Sipcam S.p.A.) ; ‘Warhawk’ (Dow AgroSciences) ; ‘Whirlwind’ (Helena) ; ‘X-Phos’ (Zagro) ; ‘Yuma’ (Dow AgroSciences) mixtures ‘Anaconda’ (+ cypermethrin) (Aimco, Aimco) ; ‘Anth’ (+ cypermethrin) (Krishi Rasayan, Krishi Rasayan) ; ‘Arriban’ (+ cypermethrin) (Hektaş, Hektaş) ; ‘Bancyp’ (+ cypermethrin) (Devidayal, Devidayal) ; ‘Bombard’ (+ cypermethrin) (Zagro, Zagro) ; ‘Brodan’ (+ fenobucarb) (Planters Products, Planters Products) ; ‘Chlorcyrin’ (+ cypermethrin) (Chemia, Chemia) ; ‘Cobalt’ (+ gamma-cyhalothrin) (Dow AgroSciences, Dow AgroSciences) ; ‘Cobra’ (+ cypermethrin) (Zagro, Zagro) ; ‘Concentrate 2’ (+ cypermethrin) (Trithin, Trithin) ; ‘Contra Insect Plus’ (+ cypermethrin) (Frunol, Frunol) ; ‘Corelle’ (+ cypermethrin) (Premier.Shukuroglou, Premier.Shukuroglou) ; ‘Cosmos’ (+ cypermethrin) (Chimiberg, Chimiberg) ; ‘Cyclone’ (+ cypermethrin) (Ancom, Ancom) ; ‘Cyperfos’ (+ cypermethrin) (Plaaskem S.A., Plaaskem S.A.) ; ‘Delicia Omexan-forte’ (+ bioallethrin) (Frunol, Frunol) ; ‘Delicia perma-forte’ (+ bioallethrin) (Frunol, Frunol) ; ‘Detmol du’ (+ dichlorvos) (Kemio, Kemio) ; ‘Dorsan-C’ (+ cypermethrin) (Luxembourg, Luxembourg) ; ‘Fighter’ (+ cypermethrin) (Zagro, Zagro) ; ‘Geotion’ (+ cypermethrin) (Phyteurop, Phyteurop) ; ‘Ghambhir’ (+ cypermethrin) (Ramcides, Ramcides) ; ‘Judwaa’ (+ cypermethrin) (Sulphur Mills, Sulphur Mills) ; ‘Koranda’ (+ cypermethrin) (Rallis, Rallis) ; ‘Lexan Forte’ (+ zeta-cypermethrin) (Kwizda, Kwizda) ; ‘Matador Mix’ (+ cypermethrin) (Doğal, Doğal) ; ‘Maxihit’ (+ alpha-cypermethrin) (Crop Health, Crop Health) ; ‘Mega C-505’ (+ cypermethrin) (Crop Health, Crop Health) ; ‘Metra-Side CTP’ (+ piperonyl butoxide + tetramethrin) (Trithin, Trithin, Trithin) ; ‘Nurelle D’ (+ cypermethrin) (Dow AgroSciences, Dow AgroSciences) ; ‘Omexan’ (+ bioallethrin) (Frunol, Frunol) ; ‘Orbit’ (+ cypermethrin) (Siapa, Siapa) ; ‘Param’ (+ cypermethrin) (Heranba, Heranba) ; ‘Pestan super’ (+ cypermethrin) (Efthymiadis, Efthymiadis) ; ‘Pirel-D’ (+ cypermethrin) (Herbos, Herbos) ; ‘Pull Up’ (+ endosulfan) (Probelte, Probelte) ; ‘Pyrinex Quick’ (+ deltamethrin) (Makhteshim-Agan, Makhteshim-Agan) ; ‘Sadicloato’ (+ dimethoate) (Cequisa, Cequisa) ; ‘Salut’ (+ dimethoate) (BASF, BASF) ; ‘Shixian’ (+ cypermethrin) (Fengshan, Fengshan) ; ‘Terraguard Plus’ (+ cypermethrin) (Gharda, Gharda) ; ‘Twins’ (+ cypermethrin) (Sulphur Mills, Sulphur Mills) ; ‘Ulka’ (+ cypermethrin) (Biostadt, Biostadt) ; ‘Vikrant’ (+ quinalphos) (Aimco, Aimco) ; ‘Wing Tip’ (+ dimethoate) (Probelte, Probelte) ; ‘Bolton’ (+ gamma-cyhalothrin) (Cheminova, Cheminova) Discontinued products ‘Bullet *’ (Mitsu) ; ‘Chlorfos *’ (Dow AgroSciences) ; ‘Choir *’ (Nufarm UK) ; ‘Kribon *’ (Krishi Rasayan) ; ‘Lethal *’ (Montari) ; ‘Pennphos-B *’ (Bábolna Bio) ; ‘Pyrivol *’ (Ralchem) ; ‘Rochlop *’ (Rotam) ; ‘Silrifos *’ (Isagro) ; ‘Talon *’ (FCC) mixtures ‘Atlas Sheriff *’ (+ dimethoate) (Atlas, Atlas) ; ‘Ideal-2 *’ (+ cypermethrin) (Indofil, Indofil) ; ‘Last Dream PBW *’ (+ methomyl + gossyplure) (Troy Biosciences, Troy Biosciences, Troy Biosciences) ; ‘Twinspan *’ (+ disulfoton) (PBI, PBI)
ANALYSIS
Product analysis by rplc with uv detection (CIPAC Handbook, 1985, 1C, 2028; 2003, K, 23; AOAC Methods, 18th Ed., 981.03). Residues determined by glc (A. Ambrus et al., J. Assoc. Off. Anal. Chem., 1981, 64, 733; AOAC Methods, 18th Ed., 985.22; Man. Pestic. Residue Anal., pp. 6, 8, 9, 13, 19; Anal. Methods Residues Pestic., 1988, Part I, M2, M5, M12) or by super-critical CO2 extraction and gc/ms determination (AOAC Methods, 18th Ed., 2002.03). See also Pestic. Anal. Man., I, 204, 302, 502, 503; ibid., II, 180.342, 185.1000, 186.1000. In soil by gc/ECD or gc/FPD (Environ. Chem. Methods). Details available from Dow AgroSciences.
ENVIRONMENTAL FATE
Animals In rats, dogs, and other mammals, following oral administration, rapid metabolism occurs, the principal metabolite being 3,5,6-trichloropyridin-2-ol. Excretion is principally in the urine. Plants Non-systemic in plants, not absorbed from soil via the roots. Residues taken up by plant tissues are metabolised to 3,5,6-trichloropyridin-2-ol, which is conjugated and sequestered. Soil/Environment In soil, chlorpyrifos is degraded at a moderate rate; DT50 (lab.) 10–120 d (25 °C); field DT50 for soil-incorporated applications 33–56 d, for soil-surface applications 7–15 d. Primary route of degradation is transformation to 3,5,6-trichloropyridin-2-ol, which is subsequently degraded to organochlorine compounds and CO2. Koc 1250–12 600.
TOXICOLOGICAL & ENVIRONMENTAL REVIEWS
JMPR Mtg. 104 (2005), 110 (2007); JMPR Evaln. I 66 (1992); JMPR Evaln. II 49 (1986); EU Rev. Rep. SANCO/3059/99 (2005). EU Status (1107/2009) Approved, 2005/72/EC.
MAMMALIAN TOXICOLOGY
Oral Acute oral LD50 for rats 135–163, guinea pigs 504, rabbits 1000–2000 mg/kg. Skin and eye Acute percutaneous LD50 for rabbits >5000 mg/kg; (tech.) for rats >2000 mg/kg. Mild skin and moderate eye irritant (rabbits). Not a skin sensitiser (guinea pigs). Inhalation LC50 (4–6 h) for rats >0.2 mg/l (14 ppb). NOEL (2 y) for rats 0.1 mg/kg b.w. daily; (18 mo) for mice 0.7 mg/kg b.w. daily; (2 y) for dogs 0.1 mg/kg b.w.. daily. Acute oral NOEL for humans 1.0 mg/kg b.w.. daily; acute dermal NOEL for humans 5.0 mg/kg b.w.. daily. ADI (JMPR) 0.01 mg/kg b.w. [1999, 2004]; (EC) 0.01 mg/kg b.w. [2005]; (EPA) aRfD 0.005 mg/kg b.w., cRfD 0.0003 mg/kg b.w. [2001]. Water GV 0.03 mg/l Other Non-teratogenic. Not genotoxic in a range of in vitro and in vivo studies (FAO Specifications). Toxicity class WHO (a.i.) II EPA (formulation) II EC classification T; R24| N; R50, R53| concn. dep.
ECOTOXICOLOGY
Birds Acute oral LD50 for mallard ducks 490, house sparrows (Passer domesticus) 122, chickens 32–102 mg/kg. Dietary LC50 (8 d) for mallard ducks 180, bobwhite quail 423 ppm. Fish LC50 (96 h) for bluegill sunfish 0.002–0.010, rainbow trout 0.007–0.051, roach 0.25, fathead minnows 0.12–0.54 mg/l. Daphnia LC50 (48 h) 1.7 μg/l. Algae NOEC for Selenastrum capricornutum >0.4 mg/l. Other aquatic spp. LC50 for Korean shrimps (Palaemon macrodactylus) 0.05 μg/l. Bees Toxic to bees. LD50 (oral) 360 ng/bee; (contact) 70 ng/bee. Worms LC50 (14 d) for Eisenia foetida 210 mg/kg soil. Other beneficial spp. Harmful to Carabidae and Staphylinidae (IOBC); ED50 (96 h) for Tenebrionidae c. 60 μg/kg b.w. (FAO Specifications). Toxic to Collembola (J. A. Wiles & G. K. Frampton, Pestic. Sci., 1996, 47, 273).

Copyright(C)2018, Shanghai E-Tong Chemical Co.,Ltd. All Rights Reserved. Supported by ChemNet ChinaChemNet Toocle Copyright Notice